Does fluoride accumulate in the body?
Yes. Approximately half of each day's fluoride intake will be retained. This is what makes it so dangerous. "The dose makes the poison". All sides agree to the fact that healthy kidneys can eliminate only about 50% of daily fluoride intake. The rest gets absorbed in calcified tissues, like bones and teeth.
The National Academy Of Sciences (NAS) stated in 1977 that, for the average individual, a retention of 2mg/day would result in crippling skeletal fluorosis after 40 years. Considering the above-mentioned intake level, it is likely that skeletal fluorosis already affects a significant portion of the population.
Children, the elderly and any person with impaired kidney function (which includes many
AIDS patients), are in the high-risk group for fluoride poisoning and must be warned to monitor their fluoride intake. Also at high risk are people with immunodeficiencies, diabetes and heart ailments, as well as anyone with calcium, magnesium and Vitamin C deficiencies.
(At the level of 0.4 ppm renal (kidney) impairment has been shown.) (Junco, L.I. et al, "Renal Failure and Fluorosis", Fluorine & Dental Health, JAMA 222:783 - 785, 1972)